We are happy to introduce our new RCMS publication about our recent addition to ms.epfl.ch toolbox: Aom2S. It was designed specifically for the automated analysis of oligonucleotide HR–MS/MS data. Aom2S offers the possibility to identify main type of fragments together with a-B ions, neutral losses, base losses and internal fragments. The assignment of all these product ions for different modified DNA/RNA molecules and localization of variable modifications can be successfully achieved in a few seconds. As usual, this new application is continuously evolving and regularly improved. We are delighted to share your results using Aom2s in ms.epfl.ch!