The ISIC-EPFL mass spectrometry platform team present a poster at the American society of mass spectrometry (ASMS2020) annual conference. Unfortunately, this year the Face-to-Face 68th ASMS Conference was cancelled due to the COVID-19 pandemic. Even if recording a talk is completely different from present a poster, we are excited to present this poster and video summarizing over 10 years of work. We introduce the old & new functionalities of ms.epfl.ch. As you can see surfing in the web page, the ISIC-EPFL MStoolbox can be used for a wide range of HRMS applications: (i) Basic theoretical calculations, (ii) Easycont to track classical contaminants or generate your own database, (iii) Apm2s which calculates all possible fragmentations from a given protein/peptide sequence (iv) The new oligonucleotide tool, Aom2s, for characterization of DNA/RNA fragment ions, (v) MSPolyCalc which offers assisted data interpretation to target the needs of polymer chemist and (vi) Advanced data analysis of complex samples with mixture. Download the poster here.